FELIDAE - CARNIVORE

Recommendations

1. GnRH Agonists - Gonadotropin Releasing Hormone Agonists are considered the safest reversible contraceptives, but duration of efficacy can be unpredictable. To date, data for carnivores indicate time to reversal is extremely variable, with time from implant insertion to birth of offspring ranging from 1-6 years. However, there appear to be trends within carnivore groups showing some taxa reversing more quickly on average than others. Side effects are generally similar to those associated with gonadectomy, especially the potential for weight gain unless diet is controlled.
   • Suprelorin® (deslorelin) Implants (F or M)
   • Lupron® Depot Injection (F or M)
2. Ovariohysterectomy or Ovariectomy (F) or Castration (M) are safe and effective methods for preventing pregnancy if permanent sterilization is an option (but see Caution 1 for males).

Recommended With Caution or Under Special Circumstances

1. Progestin contraceptives are associated in felids with progressive uterine growth that can result in infertility, infections, and sometimes uterine cancer; mammary tissue stimulation also can result in cancer.
2. For genetically valuable females or for females in which short-term (i.e.,
3. Progestins should not be used in pregnant animals, since they may suppress uterine contractions necessary for normal parturition. Thus, progestins should only be administered to females CONFIRMED non-pregnant.
4. If a progestin is used, treatment should only be short term, because of the increased likelihood of side effects with prolonged exposure.
5. If a progestin is used, treatment should start well BEFORE any signs of proestrus, since the elevated endogenous estrogen can exacerbate side effects of the progestin.
6. Using progestins in felids:
   • MGA Implant for 2 years, then remove for pregnancy if possible; non-fertile ovulatory cycles do not substitute for pregnancy in reversing deleterious effects on the uterus; not recommended for more than a total of 4 years (F).
   • Megestrol acetate for seasonal breeders, but for no more than 2 consecutive seasons (F).
   • Depo-Provera® injection (F) - 5mg/kg body wt. every 2 months, no more than 2 consecutive seasons. For felids, Depo-Provera is the least preferable of the progestins due to the unpredictable duration of efficacy and because it has more side effects.

Recommendation for Suprelorin® (deslorelin) Implant Use in Female Lions

1. Implants DO NOT need to be replaced at implant “expiration”. Use behavior and hormone monitoring for signs of return to cyclicity before replacing implants. Otherwise, we recommend implant replacement only every TWO years (9.4mg implants).
2. Place implants in alternative sites (e.g. base of the ear, inner thigh, or umbilical region) and remove old implants when new implants are placed, or when a breeding recommendation is made, even if implants are “expired” to reduce exposure and duration of efficacy.

Cautions

1. Vasectomy of males will not prevent potential adverse effects to females from prolonged exposure to endogenous progesterone associated with the obligate hormonal pseudo-pregnancy that follows ovulation in most felids. Endogenous progesterone and progestin contraceptives cause similar side effects.

2. PZP vaccine efficacy and safety have only been demonstrated in pinnipeds and bears among the carnivores. In other carnivores, there is mounting evidence that anti-PZP antibodies do not cross-react with the sperm receptor on the ovum, or may cause depletion of ovarian oocytes. PZP is contraindicated in species in which pseudopregnancy is common.

Research and Monitoring

1. Surveillance for deleterious effects
   • Contraception Annual Survey
   • Tissue Submission Form – Pathology
   • Adverse Reactions Report

THE USE OF ANY CONTRACEPTIVE IN NON-DOMESTIC ANIMALS IS CONSIDERED EXPERIMENTAL

(M=MALE-DIRECTED, F=FEMALE-DIRECTED METHOD)